Medical studies and science

Medical studies and science

The beginning of research into stem cells from fatty tissue dates back to over a century ago. Various scientists have conducted a large number of studies in cooperation with renowned academic institutions and clinics since then. The results show that stem cells from fatty tissue open up new therapeutic potential for us.


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Important publications and references on modern stem cell therapy with autologous stem cells from adipose tissue:—————————————

1. Freitag J, Bates D, Wickham J et al (2019) Adipose derived mesenchymal stem cell therapy in the treatment of knee osteoarthritis: a randomized controlled trial. RegenMed 14:213–230.https://

2. Lu L, Dai C, Zhang Z et al (2019) Treatment of knee osteoarthritis with intra-articularinjection of autologous adipose-derived mesenchymal progenitor cells: a prospective, randomized, double-blind,active-controlled,phaseIIbclinical trial.Stem Cell Res Ther. s13287-019-1248-3

3. Lee WS, Kim HJ, Kim KI, Kim GB, Jin W (2019) Intra Articular Injection of Autologous Adipose Tissue Derived Mesenchymal Stem Cells for the Treatment of Knee Osteoarthritis: A Phase IIb, Randomized, Placebo-Controlled Clinical Trial. Stem Cells Transl Med8(6):504–511.

4. Zhao X, Ruan J, Tang H et al (2019) Multicompositional MRI evaluation of repair cartilage in knee osteoarthritis with treatment of allogeneic humanadipose-derived mesenchymal progenitor cells. Stem Cell Res Ther. s13287-019-1406-7

5. Pers Y-M, Rackwitz L, Ferreira R et al (2016) Adipose mesenchymal stromal cell-based therapy for severe osteoarthritis of the knee: a phase I dose escalation trial. Stem Cells Transl Med5:847–856.

6. Kuah D, Sivell S, Longworth T et al (2018) Kuah D, Sivell S, Longworth T et al (2018) Safety, tolerability and efficacy of intra-articular progenza in knee osteoarthritis: a randomized double-blind placebo-controlled single ascending dose study. J Transl Med.

7. Zheping Hong Jihang Chen, Shuijun Zhang. Intra-articular injection of autologous adipose-derived stromal vascular fractions for knee osteoarthritis: a double-blind randomized self-controlled trial International Orthopaedics (2019) 43:1123–1134

8. Carlo Dall’Oca, Stefano Breda, Nicholas Elena, Roberto Valentini, Elena Manuela Samaila, Bruno Magnan. Mesenchymal Stem Cells Injection in Hip Osteoarthritis: Preliminary Results. Acta Biomed. 2019 Jan 10;90(1-S):75-80. doi: 10.23750/abm.v90i1-S.8084.

9. Mardones R, Jofré CM, Tobar L, Minguell JJ. Mesenchymal stem cell therapy in the treatment of hip osteoarthritis. J Hip Preserv Surg. 2017 Mar 19;4(2):159-163. doi:10.1093/jhps/hnx011.

10. Solvig Diederichs Wiltrud Richter. Stammzelltherapie Was unterscheidet expandierte Zellen, Fettgewebsaufbereitungen und Knochenmarkaspirate? Arthroskopie 2020 Bd. 33 Seiten 67-70

11. GE Winnier, C Alt, EU Alt et al. Isolation of adipose tissue derived regenerative cells from human subcutaneous tissue with or without the use of an enzymatic reagent. PLOS ONE | September 3, 2019

12. Eckhard U. Alt, Glenn Winnier, Alexander Haenel, Ralf Rothoerl, Oender Solakoglu, Christopher Alt, Christoph Schmitz, (A comprehensive understanding of UA-ADRCs (uncultured, autologous, fresh, unmodified, adipose derived regenerative cells, isolated at point of care) in regenerative medicine. Cells 2020 Apr 29;9(5).

13. Hurd JL, Alt C, Alt EU et al. Safety and efficacy of treating symptomatic, partialthickness rotator cuff tear with fresh, uncultured, unmodified, autologous adipose derived regenerative cells (UA-ADRCs) isolated at point of care: a prospective, randomized, controlled first-in-human pilot study J Orthop Surg Res. 2020 Mar 30;15(1):122. doi: 10.1186/s13018-020-01631-8.

14. Koh YG, Kwon OR, Kim YS, Choi YJ (2014) Comparative outcomes of open-wedge high tibial osteotomy with platelet-rich plasma alone or in combination with mesenchymal stem cell treatment: a prospective study. Arthroscopy 30:1453-60

15. Koh YG, Choi YJ, Kwon SK, Kim YS, Yeo JE (2015) Clinical results and second-look arthroscopic findings after treatment with adipose-derived stem cells for knee osteoarthritis. Knee Surg Sports Traumatol Arthrosc 23:1308–1316

16. Vangsness CT Jr, Farr J 2nd, Boyd J, Dellaero DT, Mills CR, LeRoux-Williams M (2014) Adult human mesenchymal stem cells delivered via intra-articular injection to the knee following partial medial meniscectomy: a randomized, double-blind, controlled study. J Bone Jt Surg Am 96:90–98

17. Eder C, Schmidt-Bleek K, Geissler S, Sass FA, Maleitzke T, Pumberger M, Perka C, Duda GN, Winkler T. Mesenchymal stromal cell and bone marrow concentrate therapies for musculoskeletal indications: a concise review of current literature. Mol Biol Rep. 2020 Jun;47(6):4789-4814. doi: 10.1007/s11033-020-05428-0. Epub 2020 May 25.